Probiotics Powder
Bifidobacterium Bifidum powder
Bifidobacterium bifidum is a key commensal bacterium in the healthy human gut. It excels in colonizing the intestinal mucosa and exhibits excellent acid and bile tolerance.By competitively inhibiting pathogenic bacteria, enhancing intestinal barrier func
Description
Can Bifidobacterium bifidum enhance immunity?
Yes. Numerous clinical studies have confirmed that Bifidobacterium bifidum can significantly enhance immune function through multiple mechanisms.
Core Mechanisms of Action:
1. Strengthening the intestinal barrier – the first line of immunity
The intestine is the body’s largest immune organ. Studies have shown that the unique strain Bifidobacterium bifidum BB1 can inhibit NF‑κB activation via the TLR‑2 signaling pathway and upregulate PPAR‑γ expression, significantly strengthening the intestinal epithelial barrier. This protects against leaky gut and barrier damage, thereby reducing invasion by harmful substances and lowering systemic inflammation.
2. Activating immune cells and humoral immunity
Bifidobacterium bifidum activates the immune system through multiple pathways.Bifidobacterium bifidum FL‑228.1 can significantly enhance phagocytic activity of RAW264.7 macrophages, natural killer (NK) cell activity in the spleen, serum IgG levels, and splenic lymphocyte transformation. It also upregulates the expression of antimicrobial peptide‑related genes, providing comprehensive improvement to the innate immune system.In low‑birth‑weight infants, both live and inactivated Bifidobacterium bifidum OLB6378 can improve humoral immunity. Inactivated cells show stronger effects in enhancing intestinal mucosal secretory IgA and early serum IgG, with excellent safety profiles.
3. Regulating T‑cell differentiation and immune balance
Bifidobacterium bifidum effectively regulates T‑cell differentiation and balances immune responses.Bifidobacterium bifidum NCC 453 promotes the differentiation of CD4⁺ T lymphocytes into regulatory T cells (Treg) and is one of the strongest strains for inducing interferon‑γ in Th2‑biased environments, shifting established Th2 responses toward a Th1/Treg response.In improving necrotizing enterocolitis (NEC), Bifidobacterium bifidum effectively corrects Th17/Treg imbalance and preserves intestinal barrier function.
4. Preventing allergic diseases
Bifidobacterium bifidum shows significant effects in preventing and alleviating allergies.A randomized controlled clinical trial in cesarean‑delivered newborns showed that supplementation with Bifidobacterium bifidum PRL2010 significantly reduced the incidence of atopic dermatitis, upper and lower respiratory tract infections, and dyspepsia syndrome.Bifidobacterium bifidum FB3‑12 effectively inhibits OVA‑specific IgE, mast cell protease‑1, and histamine levels in the serum of allergic mice, restores splenic Th2/Th1 immune imbalance, and repairs intestinal injury and inflammation.Bifidobacterium bifidum CBT‑BF3 reduces mRNA expression of Th2 and Th17 transcription factors and cytokines, increases expression of Treg transcription factors and cytokines, and improves atopic dermatitis by regulating T‑cell differentiation and gut microbiota.
5. Maternal‑offspring immune transmission
Maternal supplementation with Bifidobacterium bifidum TMC3115 during pregnancy profoundly affects offspring gut microbiota composition and immune system development, induces immune tolerance to food allergens, and provides immune protection by modulating gut microbiota and short‑chain fatty acid production.
| Product Name: | Bifidobacterium bifidum Powder |
| Strain name: | Bifidobacterium bifidum |
| Strain identification: | Characteristic by API 50CH&16S rDNA |
| Type: | Freeze dried powder |
| Packing: | 1kg/bag, 5kg/bag in cold-chain package |
| Storage: | Package sealed at 4℃ or refrigeration - 18℃ |
| Shelf life: | 24 months from date of production |
| Certfication: | NSF, HACCP, ISO9001, Kosher, HALAL |
| Documents support: | Genetic identification report |
| IDA deposit certificate | |
| Certificate of analysis | |
| Stability study report | |
| Anti-bile salt & Anti gastro-acid study report | |
| Antibiotic sensitivity test certificate | |
| Safety study report | |
| Microbial Enumeration method |
| Descrption: | Fine powder, no caking, no abnormal odor, no visible foreign bod |
| Color: | White to light yellow |
| Mositure: | NMT 5.0% |
| Water activity: | < 0.12% |
| Viable cell count: | NLT 500 billion cfu/gram |
| Non LAB count: | < 5000 cfu/g |
| Yeast &mould: | NMT 50 cfu/g |
| Coliform: | < 10 cfu/g |
| Pathogenic bacteria: | Negative |
| Lead(Pb): | NMT 0.5 mg/kg |
| Arsenic(As): | NMT 0.5 mg/kg |
| Cadmium(Cd): | NMT 1.0 mg/kg |
| Mercury(Hg): | NMT 0.1 mg/kg |
1.Enhances intestinal barrier functionInhibits NF κB activation through the TLR 2 signaling pathway and upregulates PPAR γ expression, significantly improving the integrity of the intestinal epithelial barrier, reducing intestinal permeability, preventing “leaky gut”, and decreasing the entry of endotoxins and pathogens into the blood.
2.Activates immune cells and humoral immunityImproves phagocytic activity of macrophages, natural killer (NK) cell activity, serum IgG levels and splenic lymphocyte transformation ability, upregulates the gene expression of antimicrobial peptides, and comprehensively enhances innate immunity. Inactivated strains can also increase intestinal mucosal sIgA and early serum IgG.
3. Regulates T cell differentiation and immune balancePromotes the differentiation of CD4⁺ T cells into regulatory T cells (Treg), shifts established Th2 responses toward Th1/Treg responses, and corrects Th17/Treg imbalance, thereby balancing immunity and alleviating inflammation.
4.Prevents and alleviates allergic diseasesClinical studies confirm that supplementation with Bifidobacterium bifidum significantly reduces the incidence of atopic dermatitis and upper/lower respiratory tract infections. It inhibits OVA specific IgE, mast cell protease and histamine levels, restores Th2/Th1 balance, and improves eczema and allergic symptoms.
5.Maternal offspring immune transmissionSupplementation with Bifidobacterium bifidum during pregnancy profoundly affects the gut microbiota composition and immune system development of offspring, induces immune tolerance to food allergens, and provides transgenerational immune protection by regulating the microbiota and short chain fatty acid production.
6.Resists pathogenic infectionsIncreases intestinal IgA levels and the number of IgA⁺ cells, reduces the load of pathogenic bacteria such as ETEC, alleviates intestinal tissue damage and systemic inflammatory responses, while protecting beneficial flora and counteracting pathogen induced dysbiosis.
7.Specific immune activationWhen utilizing human milk oligosaccharides (such as 2’ FL) as the carbon source, bacterial components show anti inflammatory effects, while metabolites stimulate immune activation, participating in precise immune regulation through different pathways.
1.Clear Strain OriginIsolated from the intestinal tract of healthy humans with well-defined strain designations (e.g., BB1, FL-228.1, PRL2010, TMC3115, etc.). Whole-genome sequencing and 16S rRNA identification reports are available, with a clear genetic background.
2.Excellent Acid and Bile TolerancePossesses strong resistance to gastric acid and bile, allowing viable bacteria to pass through the gastrointestinal tract smoothly and colonize the colonic mucosa, ensuring stable probiotic efficacy.
3.Strong Intestinal Mucosa Colonization AbilityExcels at adhering to intestinal epithelial cells, competitively blocking colonization sites of pathogenic bacteria, and maintaining long-term intestinal microecological balance. It is especially suitable for repairing damaged mucosa.
4.Dual Immunomodulatory PropertiesExhibits anti-inflammatory effects through bacterial components and stimulates immune activation via metabolites, achieving bidirectional and precise immune regulation to meet the needs of different health conditions.
Q1: Can Bifidobacterium bifidum really enhance immunity?
A: Yes. Clinical studies confirm that it can boost the activity of macrophages and NK cells, increase serum IgG and intestinal mucosal sIgA, regulate the differentiation of T cells into Treg cells, and shift a Th2‑biased response toward a Th1/Treg response, thereby comprehensively enhancing immunity and reducing the risk of infections and allergies.
Q2: How does Bifidobacterium bifidum help with allergies?
A: Multiple studies show that supplementation with Bifidobacterium bifidum significantly reduces the incidence of atopic dermatitis, eczema, and respiratory infections. It inhibits OVA‑specific IgE and mast cell proteases, restores Th2/Th1 balance, and improves allergic constitution at the root.
Q3: Is Bifidobacterium bifidum suitable for infants and young children?
A: Yes, it is. Several strains (such as PRL2010) have been clinically proven in cesarean newborns to reduce the incidence of dermatitis and infections. They are certified as FDA GRAS and EU QPS, and are included in China’s List of Strains Available for Infant and Young Children’s Food (specific strains must be confirmed). Suitable for use in infant formula and probiotic drops.
