Why is Bifidobacterium adolescentis known as the "Longevity Bacterium"?
Views : 3
Update time : 2026-04-21 09:45:27
Bifidobacterium adolescentis is a dominant strain in the intestinal tract of healthy adults. Its abundance declines markedly with age — the level of Bifidobacterium adolescentis in the intestines of people over 60 is significantly lower than that in younger individuals. This discovery has sparked extensive scientific research into whether supplementing Bifidobacterium adolescentis can delay aging.
In practical applications, thanks to its unique anti-aging properties, Bifidobacterium adolescentis has become a core ingredient in nutritional supplements for middle-aged and elderly people, metabolic health formulas and gut health products. It is also traditionally used to boost digestion, relieve constipation and enhance immunity, with antibacterial activity against common opportunistic intestinal pathogens including Enterobacter, Enterococcus and Bacteroides.
So how exactly has Bifidobacterium adolescentis earned its reputation as the longevity bacterium? Three major scientific findings reveal its anti-aging mechanisms:
1.Lifespan extension across multiple species
A 2021 study published in Nature Aging confirmed that Bifidobacterium adolescentis supplementation alleviates osteoporosis and neurodegeneration in premature aging mice, and significantly extends both healthspan and lifespan in fruit flies and nematodes. The mechanism is associated with regulating catalase activity and host metabolism.
2.Reversing muscle aging (sarcopenia)
Research in Cell Reports (2025) showed that niacin produced by Bifidobacterium adolescentis restores muscular NAD⁺ levels, suppresses the FoxO3/Atrogin-1/Murf-1 pathway to reduce muscle atrophy, and activates the SIRT1/PGC-1α axis to promote mitochondrial biogenesis, effectively improving age-related sarcopenia.
3.Participating in melatonin synthesis
The strain contains key enzymes for melatonin production, and animal experiments have verified that it can significantly regulate host melatonin levels.
Human clinical evidence:A randomized controlled trial (VITAL Study) targeting middle-aged and elderly people aged 40–75 is evaluating the effects of daily intake of ≥8×10⁹ CFU strain iVS-1 on aging markers such as DNA methylation.
In practical applications, thanks to its unique anti-aging properties, Bifidobacterium adolescentis has become a core ingredient in nutritional supplements for middle-aged and elderly people, metabolic health formulas and gut health products. It is also traditionally used to boost digestion, relieve constipation and enhance immunity, with antibacterial activity against common opportunistic intestinal pathogens including Enterobacter, Enterococcus and Bacteroides.
So how exactly has Bifidobacterium adolescentis earned its reputation as the longevity bacterium? Three major scientific findings reveal its anti-aging mechanisms:
1.Lifespan extension across multiple species
A 2021 study published in Nature Aging confirmed that Bifidobacterium adolescentis supplementation alleviates osteoporosis and neurodegeneration in premature aging mice, and significantly extends both healthspan and lifespan in fruit flies and nematodes. The mechanism is associated with regulating catalase activity and host metabolism.
2.Reversing muscle aging (sarcopenia)
Research in Cell Reports (2025) showed that niacin produced by Bifidobacterium adolescentis restores muscular NAD⁺ levels, suppresses the FoxO3/Atrogin-1/Murf-1 pathway to reduce muscle atrophy, and activates the SIRT1/PGC-1α axis to promote mitochondrial biogenesis, effectively improving age-related sarcopenia.
3.Participating in melatonin synthesis
The strain contains key enzymes for melatonin production, and animal experiments have verified that it can significantly regulate host melatonin levels.
Human clinical evidence:A randomized controlled trial (VITAL Study) targeting middle-aged and elderly people aged 40–75 is evaluating the effects of daily intake of ≥8×10⁹ CFU strain iVS-1 on aging markers such as DNA methylation.
